Nonthyroidal Illness Syndrome:
نویسنده
چکیده
Low T3 States Nonthyroidal Illness Syndrome With Low Serum T4 Physiologic Interpretations of NTIS Serum Hormone Levels and Tissue Hormone Supplies in NTIS Is There Evidence for Substances in Serum Which Can Affect T4 Binding to Proteins? TSH Levels Thyroid Hormone Turnover T4 Entry Into Cells and Generation of T3 Thyroid Hormone in Tissues Organ Specific Responses In NTIS Are Patients With NTIS Clinically Hypothyroid? Mechanism of Thyroid Hormone Suppression in NTIS Cytokines in NTIS Other Factors Altering Serum T4 Supply Diagnosis Is Thyroid Hormone Treatment of NTIS Advantageous or Disadvantageous? If Thyroid Hormone Replacement Is Given, What Should It Be? Additional Supportive Hormonal Therapy to Consider Conclusions
منابع مشابه
Abnormalities of Thyroid Hormone Metabolism during Systemic Illness: The Low T3 Syndrome in Different Clinical Settings
Thyroid hormone abnormalities are common in critically ill patients. For over three decades, a mild form of these abnormalities has been described in patients with several diseases under outpatient care. These alterations in thyroid hormone economy are a part of the nonthyroidal illness and keep an important relationship with prognosis in most cases. The main feature of this syndrome is a fall ...
متن کاملDissociation of the early decline in serum T(3) concentration and serum IL-6 rise and TNFalpha in nonthyroidal illness syndrome induced by abdominal surgery.
The etiology of the prompt decline in serum T(3) in patients with nonthyroidal illness syndrome has not been adequately explained. It has been attributed to various parameters, including test artifacts, inhibitors of T(4) and T(3) binding to proteins, decreased 5'-deiodinase activity, and circulating cytokines. Currently, much attention is centered on the role of IL-6 and TNFalpha in developing...
متن کاملComment on dangerous dogmas in medicine: the nonthyroidal illness syndrome.
For more than 3 decades it has been known that serum thyroid hormone levels drop during starvation and illness. In mild illness, this involves only a decrease in serum T3 levels. However, as the severity of the illness increases, there is a drop in both serum T3 and T4 (1). This decrease in serum thyroid hormone levels is seen in starvation (2), sepsis (3, 4), surgery (5), myocardial infarction...
متن کاملIsolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity
AIM This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level. MATERIALS AND METHODS The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated. RESULTS Anti-TPO positivity was significa...
متن کاملNonthyroidal illnesses syndrome in full-term newborns with sepsis.
OBJECTIVE To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis. MATERIALS AND METHODS We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 1...
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